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Article

Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2000

Liu M, Pleasure S J, Collins A E, Noebels J L, Naya F J, Tsai M J, Lowenstein D H

Abstract excerpt

BETA2/NeuroD is a homologue of the Drosophila atonal gene that is widely expressed during development in the mammalian brain and pancreas. Although studies in Xenopus suggest that BETA2/NeuroD is involved in cellular differentiation, its function in the mammalian nervous system is unclear. Here we show that mutant mice homozygous for a deletion at the BETA2/NeuroD locus fail to develop a granule cell layer within...

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Identifiers

PMID: 10639171
DOI: 10.1073/pnas.97.2.865
PMCID: PMC15422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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