Mouse development and cell proliferation in the absence of D-cyclins.

doi:10.1016/j.cell.2004.07.025

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mouse development and cell proliferation in the absence of D-cyclins.

Cell - 20 Aug 2004

Kozar Katarzyna, Ciemerych Maria A, Rebel Vivienne I, Shigematsu Hirokazu, Zagozdzon Agnieszka, Sicinska Ewa, Geng Yan, Yu Qunyan, Bhattacharya Shoumo, Bronson Roderick T, Akashi Koichi, Sicinski Piotr

Abstract excerpt

D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment and the core cell cycle machinery. We tested the requirement for D-cyclins in mouse development and in proliferation by generating mice lacking all D-cyclins. We found that these cyclin D1(-/-)D2(-/-)D3(-/-) mice develop until mid/late gestation and die due to heart abnormalities combined with a severe anemia. Our...

Topics

Animals
Blotting, Northern
Blotting, Western
CDC2-CDC28 Kinases
Cell Cycle
Cell Division
Cell Transformation, Neoplastic
Cyclin A
Cyclin D1
Cyclin D2
Cyclin D3
Cyclin E
Cyclin-Dependent Kinase 2

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cyclin-Dependent Kinase Inhibitor p16

Cyclins

Embryo, Mammalian

Fibroblasts

Flow Cytometry

Source

Open in PubMed

Identifiers

PMID: 15315760
DOI: 10.1016/j.cell.2004.07.025

Genes

CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.