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Article

Impaired Generation of Transit-Amplifying Progenitors in the Adult Subventricular Zone of Cyclin D2 Knockout Mice.

Cells - 1 Jan 2022

Płatek Rafał, Rogujski Piotr, Mazuryk Jarosław, Wiśniewska Marta B, Kaczmarek Leszek, Czupryn Artur

Abstract excerpt

In the adult brain, new neurons are constitutively derived from postnatal neural stem cells/progenitors located in two neurogenic regions: the subventricular zone (SVZ) of the lateral ventricles (migrating and differentiating into different subtypes of the inhibitory interneurons of the olfactory bulbs), and the subgranular layer of the hippocampal dentate gyrus. Cyclin D2 knockout (cD2-KO) mice exhibit reduced...

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PMID: 35011697
DOI: 10.3390/cells11010135
PMCID: PMC8750346

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