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[Dihydropteroate Synthase (DHPS) Gene Mutations and Mitochondrial Large Subunit (mtLSU) rRNA Genotype Variations in Pneumocystis jirovecii Strains].

Mikrobiyoloji bulteni - 1 Jan 2021

Gülbudak Harun, Öztürk Candan, Kuyugöz Sibel, Tezcan Ülger Seda

Abstract excerpt

Pneumocystis jirovecii is an atypical fungus that causes Pneumocystis pneumonia (PCP) in HIV/AIDS and immunocompromised patients. Antibiotics containing sulfa and sulfone groups are widely used in PCP prophylaxis and treatment. Especially, long-term use of trimethoprim sulfamethoxazole (TMP-SMX) is known to cause certain point mutations associated with drug resistance in the P.jirovecii dihydropteroate synthase...

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Identifiers

PMID: 33590980
DOI: 10.5578/mb.20140

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