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Article

Thrombin-unique coagulation system protein with multifaceted impacts on cancer and metastasis.

Cancer metastasis reviews - 1 Jun 2016

Wojtukiewicz Marek Z, Hempel Dominika, Sierko Ewa, Tucker Stephanie C, Honn Kenneth V

Abstract excerpt

The association between blood coagulation and cancer development is well recognized. Thrombin, the pleiotropic enzyme best known for its contribution to fibrin formation and platelet aggregation during vascular hemostasis, may also trigger cellular events through protease-activated receptors, PAR-1 and PAR-4, leading to cancer progression. Our pioneering findings provided evidence that thrombin contributes to...

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PMID: 27189210
DOI: 10.1007/s10555-016-9626-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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