Article
Segment-wise genome-wide association analysis identifies a candidate region associated with schizophrenia in three independent samples.
PloS one - 1 Jan 2012
Gladwin Thomas E, Derks Eske M, Rietschel Marcella, Mattheisen Manuel, Breuer René, Schulze Thomas G, Nöthen Markus M, Levinson Douglas, Shi Jianxin, Gejman Pablo V, Cichon Sven, Ophoff Roel A
Abstract excerpt
Recent studies suggest that variation in complex disorders (e.g., schizophrenia) is explained by a large number of genetic variants with small effect size (Odds Ratio ≈ 1.05-1.1). The statistical power to detect these genetic variants in Genome Wide Association (GWA) studies with large numbers of cases and controls (v 15,000) is still low. As it will be difficult to further increase sample size, we decided to...
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