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Article

What the papers say: where is the somatic mutation that causes aging?

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Nov 2004

Driver Christopher

Abstract excerpt

It has been proposed that somatic mutations make major contributions to aging. The first paper, based on a gene knock-in mouse, supports a contributory role for mutation in mtDNA in aging, but does not support a damaged-mtDNA-producing-more-damaged-mtDNA hypothesis. The second paper indicates som...

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PMID: 15499582
DOI: 10.1002/bies.20149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15499582-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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