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Article

Somatic mutations in aging, cancer and neurodegeneration.

Mechanisms of ageing and development - 1 Apr 2012

Kennedy Scott R, Loeb Lawrence A, Herr Alan J

Abstract excerpt

The somatic mutation theory of aging posits that the accumulation of mutations in the genetic material of somatic cells as a function of time results in a decrease in cellular function. In particular, the accumulation of random mutations may inactivate genes that are important for the functioning...

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Identifiers

PMID: 22079405
DOI: 10.1016/j.mad.2011.10.009
PMCID: PMC3325357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22079405-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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