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Article

Effect of DLK1 and RTL1 but not MEG3 or MEG8 on muscle gene expression in Callipyge lambs.

PloS one - 9 Oct 2009

Fleming-Waddell Jolena N, Olbricht Gayla R, Taxis Tasia M, White Jason D, Vuocolo Tony, Craig Bruce A, Tellam Ross L, Neary Mike K, Cockett Noelle E, Bidwell Christopher A

Abstract excerpt

Callipyge sheep exhibit extreme postnatal muscle hypertrophy in the loin and hindquarters as a result of a single nucleotide polymorphism (SNP) in the imprinted DLK1-DIO3 domain on ovine chromosome 18. The callipyge SNP up-regulates the expression of surrounding transcripts when inherited in cis without altering their allele-specific imprinting status. The callipyge phenotype exhibits polar overdominant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19816583
DOI: 10.1371/journal.pone.0007399
PMCID: PMC2756960

Genes

DLK1
DIO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Effect of DLK1 and RTL1 but not MEG3 or MEG8 on muscle gene expression in Callipyge lambs.PMID 19816583Read ↗

Postnatal changes in the expression of genes located in the callipyge region in sheep skeletal muscle.Semantic proximity Read ↗

New insights into polar overdominance in callipyge sheep.Semantic proximity Read ↗

Analysis of gene expression during the onset of muscle hypertrophy in callipyge lambs.Semantic proximity Read ↗

Expression of PEG11 and PEG11AS transcripts in normal and callipyge sheep.Semantic proximity Read ↗

Analysis of the callipyge phenotype through skeletal muscle development; association of Dlk1 with muscle precursor cells.Semantic proximity Read ↗

The Imprinted Retrotransposon-Like Gene PEG11 (RTL1) Is Expressed as a Full-Length Protein in Skeletal Muscle from Callipyge SheepSemantic proximity Read ↗

The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status.Semantic proximity Read ↗

Identification of a gene network contributing to hypertrophy in callipyge skeletal muscle.Semantic proximity Read ↗

Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype.Semantic proximity Read ↗

Callipyge mutation affects gene expression in cis: a potential role for chromatin structure.Semantic proximity Read ↗

Differential expression of the GTL2 gene within the callipyge region of ovine chromosome 18.Semantic proximity Read ↗

BEGAIN: a novel imprinted gene that generates paternally expressed transcripts in a tissue- and promoter-specific manner in sheep.Semantic proximity Read ↗

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