Article
Analysis of the callipyge phenotype through skeletal muscle development; association of Dlk1 with muscle precursor cells.
Differentiation; research in biological diversity - 1 Mar 2008
White Jason D, Vuocolo Tony, McDonagh Matthew, Grounds Miranda D, Harper Gregory S, Cockett Noelle E, Tellam Ross
Abstract excerpt
The callipyge mutation in sheep in the form of the paternal heterozygote results in skeletal muscle hypertrophy, which is most pronounced in the hindquarters. Overexpression of one of the genes in the region of the causative single-nucleotide polymorphism, Dlk1, is postulated to be a primary cause of the muscle hypertrophy although the mechanism is not clear. This study examined the expression of Dlk1 mRNA and...
Topics
- Animals
- Base Sequence
- Blotting, Western
- Cell Lineage
- DNA Primers
- Electrophoresis, Polyacrylamide Gel
- Muscle Proteins
- Muscle, Skeletal
- Phenotype