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Article

SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex.

Current biology : CB - 26 Oct 2004

Furuyama Takehito, Banerjee Rakhee, Breen Thomas R, Harte Peter J

Abstract excerpt

BACKGROUND: SIR2 was originally identified in S. cerevisiae for its role in epigenetic silencing through the creation of specialized chromatin domains. It is the most evolutionarily conserved protein deacetylase, with homologs in all kingdoms. SIR2 orthologs in multicellular eukaryotes have been implicated in lifespan determination and regulation of the activities of transcription factors and other proteins....

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Source

Identifiers

PMID: 15498488
DOI: 10.1016/j.cub.2004.09.060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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