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Article

The Drosophila melanogaster sir2+ gene is nonessential and has only minor effects on position-effect variegation.

Genetics - 1 Mar 2003

Aström Stefan U, Cline Thomas W, Rine Jasper

Abstract excerpt

Five Drosophila melanogaster genes belong to the highly conserved sir2 family, which encodes NAD(+)-dependent protein deacetylases. Of these five, dsir2(+) (CG5216) is most similar to the Saccharomyces cerevisiae SIR2 gene, which has profound effects on chromatin structure and life span. Four independent Drosophila strains were found with P-element insertions near the dsir2 transcriptional start site as well as...

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Identifiers

PMID: 12663533
DOI: 10.1093/genetics/163.3.931
PMCID: PMC1462486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Drosophila melanogaster sir2+ gene is nonessential and has only minor effects on position-effect variegation.PMID 12663533Read ↗

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