Article
[mtDNA mutations in mouse tumors].
Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 Oct 2004
Dai Ji-gang, Min Jia-xin, Zhang Guo-qiang, Wei Hong, Xiao Ying-bin
Abstract excerpt
OBJECTIVE: To investigate variations of mtDNA in mouse tumors and to explore the relationship between mtDNA mutations and murine carcinogenesis. METHODS: Variations of D-loop, ND3 and tRNAIle + Glu + Met gene fragments of mtDNA from six mouse tumor cell lines were analyzed by PCR-RFLP and PCR-SSCP techniques. RESULTS: ND3 and tRNAIle + Glu + Met gene fragments of mtDNA from the tumors showed no variations at 27...
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