Article
Internal ribosome entry site drives cap-independent translation of reaper and heat shock protein 70 mRNAs in Drosophila embryos.
RNA (New York, N.Y.) - 1 Nov 2004
Hernández Greco, Vázquez-Pianzola Paula, Sierra José M, Rivera-Pomar Rolando
Abstract excerpt
Translation is a sensitive regulatory step during cellular stress and the apoptosis response. Under such conditions, cap-dependent translation is reduced and internal ribosome entry site (IRES)-dependent translation plays a major role. However, many aspects of how mRNAs are translated under stress remain to be elucidated. Here we report that reaper mRNA, a pro-apoptotic gene from Drosophila melanogaster, is...
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