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Article

Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development.

Development (Cambridge, England) - 1 Nov 2004

Chan Richard, Hardy W Rod, Dankort David, Laing Michael A, Muller William J

Abstract excerpt

We have generated a series of Erbb2 cDNA knock-in animals to explore the role of signaling pathways coupled to Erbb2 during development. Although this knock-in allele was hypomorphic, expressing tenfold less Erbb2 protein than wild type, the knock-in animals were healthy. However, a further twofold reduction in Erbb2 levels in hemizygous knock-in animals resulted in perinatal lethality with defects in the...

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Identifiers

PMID: 15496447
DOI: 10.1242/dev.01425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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