Article
The EGFR is required for proper innervation to the skin.
The Journal of investigative dermatology - 1 Mar 2009
Maklad Adel, Nicolai Jodi R, Bichsel Kyle J, Evenson Jackie E, Lee Tang-Cheng, Threadgill David W, Hansen Laura A
Abstract excerpt
EGFR family members are essential for proper peripheral nervous system development. A role for EGFR itself in peripheral nervous system development in vivo, however, has not been reported. We investigated whether EGFR is required for cutaneous innervation using Egfr null and skin-targeted Egfr mutant mice. Neuronal markers; including PGP9.5, GAP-43, acetylated tubulin, and neurofilaments; revealed that Egfr null...
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