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Article

Analysis of complex genetic systems by ARMS-SSCP: application to HLA genotyping.

Nucleic acids research - 11 Mar 1992

Lo Y M, Patel P, Mehal W Z, Fleming K A, Bell J I, Wainscoat J S

Abstract excerpt

We have developed a new method for analysis of complex genetic systems by a combination of the Amplification Refractory Mutation System (ARMS) and Single-Strand Conformation Polymorphism (SSCP) analysis: ARMS-SSCP. Thus, a complex allelic series is subdivided into a number of groups by ARMS follo...

Topics

Base Sequence
DNA, Single-Stranded
Fluorescent Dyes
Genes, MHC Class II
Genotype
HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DR Antigens
HLA-DRB3 Chains
Humans
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Conformation

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Polymorphism, Genetic

Silver Staining

Source

Open in PubMed Open full text

Identifiers

PMID: 1549460
DOI: 10.1093/nar/20.5.1005
PMCID: PMC312083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1549460-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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