Article
Analysis of complex genetic systems by ARMS-SSCP: application to HLA genotyping.
Nucleic acids research - 11 Mar 1992
Lo Y M, Patel P, Mehal W Z, Fleming K A, Bell J I, Wainscoat J S
Abstract excerpt
We have developed a new method for analysis of complex genetic systems by a combination of the Amplification Refractory Mutation System (ARMS) and Single-Strand Conformation Polymorphism (SSCP) analysis: ARMS-SSCP. Thus, a complex allelic series is subdivided into a number of groups by ARMS followed by the identification of specific alleles using SSCP analysis. We have shown that the HLA alleles at the DRB3 and...
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