Rapid HLA typing by multiplex amplification refractory mutation system.

doi:10.1136/jcp.46.12.1105

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Article

Rapid HLA typing by multiplex amplification refractory mutation system.

Journal of clinical pathology - 1 Dec 1993

Patel P, Lo Y M, Bell J I, Wainscoat J S

Abstract excerpt

AIMS: To detect HLA susceptibility and protective alleles associated with insulin dependent diabetes mellitus (IDDM) using a multiplex amplification refractory mutation system (ARMS). These include DR3 and DR4 alleles at the DRB1 locus, presence or absence of aspartic acid at position 57 (Asp-57)...

Topics

Alleles
Arginine
Aspartic Acid
Base Sequence
DNA Primers
Diabetes Mellitus, Type 1
Disease Susceptibility
Gene Amplification
Genes, MHC Class II
HLA-DR3 Antigen
HLA-DR4 Antigen
Histocompatibility Testing
Humans
Molecular Sequence Data
Polymerase Chain Reaction

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