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Article

Direct haplotype determination by double ARMS: specificity, sensitivity and genetic applications.

Nucleic acids research - 11 Jul 1991

Lo Y M, Patel P, Newton C R, Markham A F, Fleming K A, Wainscoat J S

Abstract excerpt

We have developed a novel double Amplification Refractory Mutation System (double ARMS) using a highly polymorphic region 5' to the human delta-globin gene as a model system. The double ARMS approach involves using two allele-specific ARMS primers simultaneously during DNA amplification by the polymerase chain reaction (PCR). The resulting system is highly sensitive and more specific than single ARMS. In...

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Identifiers

PMID: 1852606
DOI: 10.1093/nar/19.13.3561
PMCID: PMC328380

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Source receipt: pubmed, retrieved 7 Sept 2026.

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