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Article

High sensitive approach for point mutation detection based on electrochemiluminescence.

Biosensors & bioelectronics - 15 Oct 2004

Zhu Debin, Xing Da, Shen Xingyan, Liu Jinfeng, Chen Qun

Abstract excerpt

An electrochemiluminescence-polymerase chain reaction (ECL-PCR) method for point mutation detection has been developed. The target is amplified using a tris (bipyridine) ruthenium (TBR)-labeled forward and a biotinylated reverse primer. The amplification products are digested with specific restriction enzyme, then captured onto streptavidin-coated paramagnetic beads, and detected by measuring the ECL signal of...

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Identifiers

PMID: 15494224
DOI: 10.1016/j.bios.2004.02.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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