Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aberrant expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma.

Human pathology - 1 Oct 2004

Cui Xing, Shirai Yoshio, Wakai Toshifumi, Yokoyama Naoyuki, Hirano Seishiro, Hatakeyama Katsuyoshi

Abstract excerpt

This study aimed to identify potential abnormalities of retinoblastoma protein (pRb) and p16(INK4a) (p16) expression in resectable colorectal carcinomas (CRCs) and to assess the prognostic significance of pRb and p16 levels in patients with CRC. From July 1990 through December 1993, 117 consecutive patients with CRC underwent curative resection with radical lymphadenectomy. The resected specimens were examined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p16

Share to Genes, Retinoblastoma

Share to Immunohistochemistry

Share to Proportional Hazards Models

Share to Retinoblastoma Protein

Share to Survival Rate

Source

Identifiers

PMID: 15492985
DOI: 10.1016/j.humpath.2004.06.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aberrant expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma.PMID 15492985Read ↗

p16 protein is upregulated in a stepwise fashion in colorectal adenoma and colorectal carcinoma.Semantic proximity Read ↗

Abnormal Expression of p16<sup>INK4a</sup>, Cyclin D1, Cyclin‐Dependent Kinase 4 and Retinoblastoma Protein in Gastric CarcinomasSemantic proximity Read ↗

Human Colorectal Cancers with an Intact p16/Cyclin D1/pRb Pathway Have Up-Regulated p16 Expression and Decreased Proliferation in Small Invasive Tumor ClustersSemantic proximity Read ↗

Analysis of key cell‐cycle checkpoint proteins in colorectal tumoursSemantic proximity Read ↗

Expression of altered retinoblastoma protein inversely correlates with tumor invasion in gastric carcinoma.Semantic proximity Read ↗

p16INK4a Is a β-Catenin Target Gene and Indicates Low Survival in Human Colorectal TumorsSemantic proximity Read ↗

Aberrations of p16Ink4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines.Semantic proximity Read ↗

Clinicoprognostic significance of pRb1 pathway alterations in uterine endometrial adenocarcinoma.Semantic proximity Read ↗

Disruption of the p16/Cyclin D1/Retinoblastoma Protein Pathway in the Majority of Human Hepatocellular CarcinomasSemantic proximity Read ↗

G1 control gene status is frequently altered in resectable non-small cell lung cancer.Semantic proximity Read ↗

Expressions of Cell Cycle Regulators in Human Colorectal Cancer Cell LinesSemantic proximity Read ↗

K-ras and p16 aberrations confer poor prognosis in human colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.