Article
Clinicoprognostic significance of pRb1 pathway alterations in uterine endometrial adenocarcinoma.
Cancer genetics and cytogenetics - 15 Oct 2004
Semczuk Andrzej, Cybulski Marek, Tomaszewski Jacek, Rechberger Tomasz, Jakowicki Jerzy A
Abstract excerpt
Components of the pRb1 pathway play a pivotal role in regulating the G1/S transition in the cell cycle. This study investigated the association between pRb1-cyclin D1-cdk4-p16INK4A pathway alterations and the clinical and prognostic utility for women affected by primary uterine endometrial adenocarcinoma (EC). The study population consisted of 50 cases of EC patients who were investigated for RB1 and CDKN2A...
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