Article
G1 control gene status is frequently altered in resectable non-small cell lung cancer.
International journal of cancer - 21 Oct 1997
Betticher D C, White G R, Vonlanthen S, Liu X, Kappeler A, Altermatt H J, Thatcher N, Heighway J
Abstract excerpt
Progression through the mammalian cell cycle is controlled by a series of cyclins, cyclin-dependent kinases (cdks) and cdk inhibitors. Cyclin D1, cdk4 and the tumour suppressors p16 and retinoblastoma protein (pRb) are thought to comprise a linked system governing cell passage through the G1 phase of the cell cycle. Extending an earlier study on cyclin D1 expression, a series of resectable non-small cell lung...
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