Article
K-ras and p16 aberrations confer poor prognosis in human colorectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Jan 2001
Esteller M, González S, Risques R A, Marcuello E, Mangues R, Germà J R, Herman J G, Capellà G, Peinado M A
Abstract excerpt
PURPOSE: Mutations in the K-ras gene are frequent in human cancer. ras activation in primary cells results in a cellular senescence phenotype that is precluded by inactivation of p16. At the clinical level, this may imply a differential behavior for tumors with alternative or cooperative activation of K-ras function and impairment of p16 pathways. PATIENTS AND METHODS: We have determined the presence of mutations...
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