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Article

Abnormal Expression of p16<sup>INK4a</sup>, Cyclin D1, Cyclin‐Dependent Kinase 4 and Retinoblastoma Protein in Gastric Carcinomas

15 May 2008

Abstract excerpt

BACKGROUND AND OBJECTIVES: The p16(INK4a) (p16), cyclin D1, cyclin-dependent kinase (CDK) 4 and retinoblastoma (Rb) genes are components of the Rb pathway that controls the G1-S checkpoint of the cell cycle. The aim of this study was to assess the relationship between their abnormalities and clinicopathological features in gastric carcinomas. METHODS: Immunohistochemical analysis of the encoded proteins was...

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PMID: 18484097
DOI: 10.1002/jso.21087

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