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Article

Genetic background determines the requirement for B7 costimulation in induction of autoimmunity.

European journal of immunology - 1 Sept 2002

Jabs Claudia, Greve Bernhard, Chang Tammy T, Sobel Raymond A, Sharpe Arlene H, Kuchroo Vijay K

Abstract excerpt

B7 costimulatory molecules play an important role in inducing autoimmunity, tumor immunity, and transplant rejection, and therapeutic manipulation of B7 is being investigated in human diseases. To determine whether B7 costimulation is essential for inducing autoimmunity on different genetic backgrounds, we backcrossed B7.1/B7.2 deficient ((-/-)) mice on to the C57BL/6 (B6) and SJL backgrounds and induced...

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Source

Identifiers

PMID: 12207354
DOI: 10.1002/1521-4141(200209)32:9<2687::AID-IMMU2687>3.0.CO;2-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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