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Article

Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2008

Zhang Hong, Podojil Joseph R, Luo Xunrong, Miller Stephen D

Abstract excerpt

Multiple sclerosis is characterized by perivascular CNS infiltration of myelin-specific CD4(+) T cells and activated mononuclear cells. TCR transgenic mice on the SJL background specific for proteolipid protein (PLP)(139-151) develop a high incidence of spontaneous experimental autoimmune encephalomyelitis (sEAE). We examined the intrinsic mechanisms regulating onset and severity of sEAE. CD4(+) T cells isolated...

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Share to Crosses, Genetic
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred Strains

Share to Myelin Proteolipid Protein

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Source

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Identifiers

PMID: 18802066
DOI: 10.4049/jimmunol.181.7.4638
PMCID: PMC2853378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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