Article
Identification of alternative splicing regulators by RNA interference in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 2004
Park Jung W, Parisky Katherine, Celotto Alicia M, Reenan Robert A, Graveley Brenton R
Abstract excerpt
Alternative splicing is thought to be regulated by nonspliceosomal RNA binding proteins that modulate the association of core components of the spliceosome with the pre-mRNA. Although the majority of metazoan genes encode pre-mRNAs that are alternatively spliced, remarkably few splicing regulators are currently known. Here, we used RNA interference to examine the role of >70% of the Drosophila RNA-binding...
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