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Article

Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.

Journal of neurochemistry - 1 Oct 2012

Muthusamy Nagendran, Faundez Victor, Bergson Clare

Abstract excerpt

Calcyon is a neural enriched, single transmembrane protein that interacts with clathrin light chain and stimulates clathrin assembly and clathrin-mediated endocytosis. A similar property is shared by the heterotetrameric adaptor protein (AP) complexes AP-1, AP-2, and AP-3 which recruit cargoes for insertion into clathrin coated transport vesicles. Here we report that AP medium (μ) subunits interact with a...

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Identifiers

PMID: 22650988
DOI: 10.1111/j.1471-4159.2012.07814.x
PMCID: PMC3813962

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