Article
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.
Molecular biology of the cell - 1 Mar 2009
Newell-Litwa Karen, Salazar Gloria, Smith Yoland, Faundez Victor
Abstract excerpt
Neuronal lysosomes and their biogenesis mechanisms are primarily thought to clear metabolites and proteins whose abnormal accumulation leads to neurodegenerative disease pathology. However, it remains unknown whether lysosomal sorting mechanisms regulate the levels of membrane proteins within synaptic vesicles. Using high-resolution deconvolution microscopy, we identified early endosomal compartments where both...
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