Article
A rho-binding protein kinase C-like activity is required for the function of protein kinase N in Drosophila development.
Genetics - 1 Aug 2007
Betson Martha, Settleman Jeffrey
Abstract excerpt
The Rho GTPases interact with multiple downstream effectors to exert their biological functions, which include important roles in tissue morphogenesis during the development of multicellular organisms. Among the Rho effectors are the protein kinase N (PKN) proteins, which are protein kinase C (PKC)-like kinases that bind activated Rho GTPases. The PKN proteins are well conserved evolutionarily, but their...
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