Article

Critical role of Gα12 and Gα13 proteins in TGF-β-induced myofibroblast differentiation

2024-05-30

Abstract excerpt

Myofibroblast differentiation, characterized by accumulation of cytoskeletal and extracellular matrix proteins by fibroblasts, is a key process in wound healing and pathogenesis of tissue fibrosis. Transforming growth factor-β (TGF-β) is the most powerful known driver of myofibroblast differentiation. TGF-β signals through transmembrane receptor serine/threonine kinases that phosphorylate Smad transcription factor...

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Literature Corpus work: dd8009ca-c2f5-5d5f-8db1-ab48c88debd2
DOI: 10.1101/2024.05.29.596473

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