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Article

Amplification-mutagenesis: evidence that "directed" adaptive mutation and general hypermutability result from growth with a selected gene amplification.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2002

Hendrickson Heather, Slechta E Susan, Bergthorsson Ulfar, Andersson Dan I, Roth John R

Abstract excerpt

When a particular lac mutant of Escherichia coli starves in the presence of lactose, nongrowing cells appear to direct mutations preferentially to sites that allow growth (adaptive mutation). This observation suggested that growth limitation stimulates mutability. Evidence is provided here that this behavior is actually caused by a standard Darwinian process in which natural selection acts in three sequential...

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Identifiers

PMID: 11830643
DOI: 10.1073/pnas.032680899
PMCID: PMC122336

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