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Article

Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors.

Molecular and cellular biology - 1 Oct 2002

Lagutina Irina, Conway Simon J, Sublett Jack, Grosveld Gerard C

Abstract excerpt

Alveolar rhabdomyosarcoma is a pediatric disease specified by the recurrent chromosome translocations t(2;13) and t(1;13). These translocations result in the formation of the PAX3-FKHR and PAX7-FKHR fusion genes, which are thought to play a causal role in the genesis of this disease. Although PAX3-FKHR exhibits transforming activity in immortalized fibroblast cell lines, a direct role of this fusion protein in...

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Source

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Identifiers

PMID: 12242297
DOI: 10.1128/MCB.22.20.7204-7216.2002
PMCID: PMC139793

Genes

PAX3
PAX7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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