Article
Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma.
Cancer research - 1 Apr 2009
Nishijo Koichi, Chen Qing-Rong, Zhang Lei, McCleish Amanda T, Rodriguez Andrea, Cho Min Jung, Prajapati Suresh I, Gelfond Jonathan A L, Chisholm Gary B, Michalek Joel E, Aronow Bruce J, Barr Frederic G, Randall R Lor, Ladanyi Marc, Qualman Stephen J, Rubin Brian P, LeGallo Robin D, Wang Chiayeng, Khan Javed, Keller Charles
Abstract excerpt
The highly aggressive muscle cancer alveolar rhabdomyosarcoma (ARMS) is one of the most common soft tissue sarcoma of childhood, yet the outcome for the unresectable and metastatic disease is dismal and unchanged for nearly three decades. To better understand the pathogenesis of this disease and to facilitate novel preclinical approaches, we previously developed a conditional mouse model of ARMS by faithfully...
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