Article

Delay of human early development via in vitro diapause

2023-05-29

Abstract excerpt

<h4>SUMMARY</h4> Many mammals can control the timing of gestation and birth by pausing embryonic development at the blastocyst stage. It is unknown whether the capacity to pause development is conserved, in general across mammals, and more specifically in humans. Activity of the growth regulating mTOR pathway governs developmental pausing in the mouse ( 1 ). Here we show a stage-specific capacity to delay the pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1e8fde9f-fb82-5547-9796-6297409fa736
DOI: 10.1101/2023.05.29.541316

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Delay of human early development via in vitro diapauseDOI 10.1101/2023.05.29.541316Read

Molecular Regulators of Embryonic Diapause and Cancer Diapause-like StateSemantic proximity Read

Large scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal crosstalkSemantic proximity Read

Physiologic Events of Embryo Implantation and Decidualization in Human and Non-Human PrimatesSemantic proximity Read

Transgene-Free Ex Utero Derivation of A Human Post-Implantation Embryo Model Solely from Genetically Unmodified Naïve PSCsSemantic proximity Read

The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell DormancySemantic proximity Read

Cross-species comparison of mouse and human preimplantation development with an emphasis on lineage specificationSemantic proximity Read

Control of Maternal-to-Zygotic Transition in Human Embryos and Other Animal Species (Especially Mouse): Similarities and DifferencesSemantic proximity Read

Human embryos arrest in a quiescent-like state characterized by metabolic and zygotic genome activation problemsSemantic proximity Read

Cell-autonomous differentiation of human primed embryonic stem cells into trophoblastic syncytia through the nascent amnion-like cell stateSemantic proximity Read

Hamartin regulates cessation of mouse nephrogenesis independently of MtorSemantic proximity Read

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic nicheSemantic proximity Read

Haploid Asexual Blastocyst Fitness Varies Across Mouse Strains Related to Efficiency of Exit From TotipotencySemantic proximity Read