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Article

Cooperation of the N-terminal Helicase and C-terminal endonuclease activities of Archaeal Hef protein in processing stalled replication forks.

The Journal of biological chemistry - 17 Dec 2004

Komori Kayoko, Hidaka Masumi, Horiuchi Takashi, Fujikane Ryosuke, Shinagawa Hideo, Ishino Yoshizumi

Abstract excerpt

Blockage of replication fork progression often occurs during DNA replication, and repairing and restarting stalled replication forks are essential events in all organisms for the maintenance of genome integrity. The repair system employs processing enzymes to restore the stalled fork. In Archaea Hef is a well conserved protein that specifically cleaves nicked, flapped, and fork-structured DNAs. This enzyme...

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Identifiers

PMID: 15485882
DOI: 10.1074/jbc.M409243200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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