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Article

Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity.

PloS one - 1 Jan 2014

Jung Joo In, Premraj Sasha, Cruz Pedro E, Ladd Thomas B, Kwak Yewon, Koo Edward H, Felsenstein Kevin M, Golde Todd E, Ran Yong

Abstract excerpt

Altered production of β-amyloid (Aβ) from the amyloid precursor protein (APP) is closely associated with Alzheimer's disease (AD). APP has a number of homo- and hetero-dimerizing domains, and studies have suggested that dimerization of β-secretase derived APP carboxyl terminal fragment (CTFβ, C99) impairs processive cleavage by γ-secretase increasing production of long Aβs (e.g., Aβ1-42, 43). Other studies report...

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Identifiers

PMID: 25350374
DOI: 10.1371/journal.pone.0111553
PMCID: PMC4211736

Genes

APP
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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