Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

Aging cell - 1 Dec 2015

Fuku Noriyuki, Pareja-Galeano Helios, Zempo Hirofumi, Alis Rafael, Arai Yasumichi, Lucia Alejandro, Hirose Nobuyoshi

Abstract excerpt

Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to DNA, Mitochondrial
Share to Japan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Longevity

Share to Mitochondria

Share to Open Reading Frames

Share to Peptides

Share to RNA, Ribosomal

Source

Open in PubMed Open full text

Identifiers

PMID: 26289118
DOI: 10.1111/acel.12389
PMCID: PMC4693465

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?PMID 26289118Read ↗

MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related DiseasesSemantic proximity Read ↗

Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related DiseasesSemantic proximity Read ↗

MOTS-c Functionally Prevents Metabolic DisordersSemantic proximity Read ↗

Mitochondrial-derived Peptides: Are They Actually Important?Semantic proximity Read ↗

Mitochondria‑derived peptides: Promising microproteins in cardiovascular diseases (Review)Semantic proximity Read ↗

Mitochondrial-derived peptides in cardiovascular disease: Novel insights and therapeutic opportunitiesSemantic proximity Read ↗

Mitochondrial-Derived Peptides in Diabetes and Its ComplicationsSemantic proximity Read ↗

Novel Insights into Mitochondrial DNA: Mitochondrial Microproteins and mtDNA Variants Modulate Athletic Performance and Age-Related DiseasesSemantic proximity Read ↗

Mitochondrial-derived peptides in energy metabolismSemantic proximity Read ↗

Mitochondrial-Encoded Peptide MOTS-c is an Exercise-Induced Regulator of Aging Metabolic Homeostasis and Physical CapacitySemantic proximity Read ↗

Mitochondrial genome single nucleotide polymorphisms and their phenotypes in the Japanese.Semantic proximity Read ↗

Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.