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Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China.

Experimental gerontology - 1 Dec 2011

Feng Jie, Zhang Jianyi, Liu Ming, Wan Gang, Qi Keyan, Zheng Chenguang, Lv Zeping, Hu Caiyou, Zeng Yi, Gregory Simon G, Yang Ze

Abstract excerpt

Human longevity is a complex heritable genetic trait. Based on substantial evidence from model organisms, it is clear that mitochondria play a pivotal role in aging and lifespan. However, the effects that mitochondrial genome variations have upon longevity and longevity-related phenotypes in Chuang people in China have yet to be established. By genotyping 15 variants for 10 haplogroups in 738 Chuang subjects,...

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PMID: 21945877
DOI: 10.1016/j.exger.2011.09.001

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