Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In silico design of clinical trials: A method coming of age

1 Oct 2004

Abstract excerpt

OBJECTIVE: To determine the feasibility and potential usefulness of mathematical models in evaluating immunomodulatory strategies in clinical trials of severe sepsis. DESIGN: Mathematical modeling of immunomodulation in simulated patients. SETTING: Computer laboratory. MEASUREMENTS AND MAIN RESULTS: We introduce and evaluate the concept of conducting a randomized clinical trial in silico based on simulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Response and Inflammation
Share to Sepsis Diagnosis and Treatment
Share to vaccines and immunoinformatics approaches

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15483415
DOI: 10.1097/01.ccm.0000142394.28791.c3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In silico design of clinical trials: A method coming of agePMID 15483415Read ↗

Strategies to Minimize Heterogeneity and Optimize Clinical Trials in Acute Respiratory Distress Syndrome (ARDS): Insights from Mathematical ModelingSemantic proximity Read ↗

Determining controllability of sepsis using genetic algorithms on a proxy agent-based model of systemic inflammationSemantic proximity Read ↗

Trauma in silico: Individual-specific mathematical models and virtual clinical populationsSemantic proximity Read ↗

Sepsis Reconsidered: Identifying novel metrics for behavioral landscape characterization with a high-performance computing implementation of an agent-based modelSemantic proximity Read ↗

Murine sepsis phenotypes and differential treatment effects in a randomized trial of prompt antibiotics and fluids.Semantic proximity Read ↗

Mathematical modeling of ventilator-induced lung inflammationSemantic proximity Read ↗

The Innate Immune Response to Ischemic Injury: a Multiscale Modeling PerspectiveSemantic proximity Read ↗

Ensemble Models of Neutrophil Trafficking in Severe SepsisSemantic proximity Read ↗

Target Trial Emulation of Early versus Delayed Renal Replacement Therapy in Sepsis-Associated AKI: A Causal Inference StudySemantic proximity Read ↗

Nested Active Learning for Efficient Model Contextualization and Parameterization: Pathway to generating simulated populations using multi-scale computational modelsSemantic proximity Read ↗

Analysis of Mechanistic Pathway Models in Drug Discovery: p38 PathwaySemantic proximity Read ↗

Formal Modelling of Toll like Receptor 4 and JAK/STAT Signalling Pathways: Insight into the Roles of SOCS-1, Interferon-β and Proinflammatory Cytokines in SepsisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.