Article

Strategies to Minimize Heterogeneity and Optimize Clinical Trials in Acute Respiratory Distress Syndrome (ARDS): Insights from Mathematical Modeling

2021-06-08

Abstract excerpt

Background: Mathematical deconvolution of multiple biologic pathways simultaneously active in critical illness may aid in the interpretation of clinical data.<br><br>Methods: Using a systems biology model of COVID-19, we analyze the effect of immunomodulation on diverse patient phenotypes. We define optimal treatment and optimal treatment initiation time, identify biologic programs which determine heterogeneous cl...

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Literature Corpus work: 91020f95-4855-5d45-a54d-121f006d1372
DOI: 10.2139/ssrn.3857639

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