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Article

A polymorphism in type I deiodinase is associated with circulating free insulin-like growth factor I levels and body composition in humans.

The Journal of clinical endocrinology and metabolism - 1 Jan 2005

Peeters Robin P, van den Beld Annewieke W, van Toor Hans, Uitterlinden Andre G, Janssen Joop A M J L, Lamberts Steven W J, Visser Theo J

Abstract excerpt

The interaction between the GH-IGF-I axis and thyroid hormone metabolism is complex and not fully understood. T(4) stimulates IGF-I activity in animals in the absence of GH. On the other hand, GH replacement therapy results in an increase in serum T(3) and a decrease in T(4) and rT(3) levels, suggesting a stimulation of type I deiodinase (D1) activity. Recently, we demonstrated the association of two...

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Identifiers

PMID: 15483075
DOI: 10.1210/jc.2004-1301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

A polymorphism in type I deiodinase is associated with circulating free insulin-like growth factor I levels and body composition in humans.PMID 15483075Read ↗

A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine.Semantic proximity Read ↗

A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters.Semantic proximity Read ↗

Polymorphisms in thyroid hormone pathway genes are associated with plasma TSH and iodothyronine levels in healthy subjects.Semantic proximity Read ↗

Genetics in endocrinology: genetic variation in deiodinases: a systematic review of potential clinical effects in humans.Semantic proximity Read ↗

The effect of genetic variation in the type 1 deiodinase gene on the interindividual variation in serum thyroid hormone levels: an investigation in healthy Danish twins.Semantic proximity Read ↗

Thr92Ala polymorphism in the type 2 deiodinase gene: an evolutionary perspective.Semantic proximity Read ↗

The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish.Semantic proximity Read ↗

A Step Forward in Understanding the Relevance of Genetic Variation in Type 2 Deiodinase.Semantic proximity Read ↗

Association Between a Novel Variant of the Human Type 2 Deiodinase Gene Thr92Ala and Insulin ResistanceSemantic proximity Read ↗

A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels.Semantic proximity Read ↗

Type 2 Deiodinase p.Thr92Ala polymorphism does not affect the severity of obesity and weight loss after bariatric surgerySemantic proximity Read ↗

Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients.Semantic proximity Read ↗

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