Article
Mutational activity in cell line WEHI-231.
Immunogenetics - 1 Feb 2005
Wang Clifford L, Wabl Matthias
Abstract excerpt
The cell line WEHI-231 expresses activation-induced cytidine deaminase (AID), the enzyme that mediates hypermutation and immunoglobulin class switch recombination in activated B cells. Although both the cDNA sequence and protein expression of AID appear normal, the frequency of mutation at the endogenous immunoglobulin locus is low. In this report, we have tested the mutational activity of the cell line with...
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