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Article

Progressive hair loss and myocardial degeneration in rough coat mice: reduced lysyl oxidase-like (LOXL) in the skin and heart.

The Journal of investigative dermatology - 1 Nov 2004

Hayashi Kimiko, Cao Tongyu, Passmore Howard, Jourdan-Le Saux Claude, Fogelgren Ben, Khan Subarna, Hornstra Ian, Kim Youngho, Hayashi Masando, Csiszar Katalin

Abstract excerpt

The rough coat (rc) is a spontaneous recessive mutation in mice. To identify the mutated gene, we have characterized the rc phenotype and initiated linkage mapping. The rc mice show growth retardation, cyclic and progressive hair loss, hyperplastic epidermis, abnormal hair follicles, cardiac muscle degeneration, and reduced amount of collagen and elastin in the skin and heart. The rc locus was mapped at 32.0 cM...

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Identifiers

PMID: 15482472
DOI: 10.1111/j.0022-202X.2004.23436.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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