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Article

Lysyl oxidase: Properties, regulation and multiple functions in biology

1 Feb 1998

Abstract excerpt

Lysyl oxidase (LO) is a copper-dependent amine oxidase that plays a critical role in the biogenesis of connective tissue matrices by crosslinking the extracellular matrix proteins, collagen and elastin. Levels of LO increase in many fibrotic diseases, while expression of the enzyme is decreased in certain diseases involving impaired copper metabolism. While the three-dimensional structure of the enzyme is not yet...

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PMID: 9524359
DOI: 10.1016/s0945-053x(98)90012-9

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