Article
The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene).
Matrix (Stuttgart, Germany) - 1 Jun 1992
Mariani T J, Trackman P C, Kagan H M, Eddy R L, Shows T B, Boyd C D, Deak S B
Abstract excerpt
Lysyl oxidase catalyzes the oxidation of lysine residues to alpha-aminoadipic-delta-semialdehyde. This is the first step in the covalent cross-linking of collagen and tropoelastin and results in the formation of insoluble collagen and elastic fibers in the extracellular matrix. We have characteri...
Topics
- Amino Acid Sequence
- Animals
- Blotting, Northern
- Chromosome Mapping
- Chromosomes, Human, Pair 5
- Colorectal Neoplasms
- DNA
- Extracellular Matrix Proteins
- Genes
- Genes, ras
- Genetic Predisposition to Disease
- Humans
- Hybrid Cells
- Mice
- Molecular Sequence Data