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Structure Modifications of 6-Aminoquinolones with Potent Anti-HIV Activity

28 Sept 2004

Abstract excerpt

We have recently discovered that 6-aminoquinolone derivatives could be valid leads for the development of new anti-HIV agents because of their new and diversified mode of action. In fact, studies carried out on the lead WM5 showed that this derivative is able to inhibit the Tat-mediated long terminal repeat driven transcription, an essential step in the HIV-1 replication cycle. Thus, starting from lead WM5, we...

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PMID: 15481992
DOI: 10.1021/jm049721p

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