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Article

Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative.

Antimicrobial agents and chemotherapy - 1 May 2004

Richter Sara, Parolin Cristina, Gatto Barbara, Del Vecchio Claudia, Brocca-Cofano Egidio, Fravolini Arnaldo, Palù Giorgio, Palumbo Manlio

Abstract excerpt

WM5, a 6-aminoquinolone derivative, binds with high affinity to the bulge of the trans-activation-responsive region (TAR), whereas it displays low binding affinity for the loop and stem regions of TAR and for random RNA and DNA sequences. Furthermore, WM5 disrupts the natural protein-nucleic acid complex with a 50% inhibitory concentration in the low micromolar range in both in vitro and in vivo assays.

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Source

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Identifiers

PMID: 15105155
DOI: 10.1128/AAC.48.5.1895-1899.2004
PMCID: PMC400552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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