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Article

Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors.

Bioorganic & medicinal chemistry letters - 15 Aug 2006

Ellis David, Kuhen Kelli L, Anaclerio Beth, Wu Baogen, Wolff Karen, Yin Hong, Bursulaya Badry, Caldwell Jeremy, Karanewsky Donald, He Yun

Abstract excerpt

A novel series of quinolones was discovered as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) using a structure-based approach. The lead quinolones exhibited single digit nanomolar potency in the HIV-1 replication assays. The preliminary SAR of these quinolones was also established via systematic structural modifications. These novel and potent quinolones could serve as advanced leads for further...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16782337
DOI: 10.1016/j.bmcl.2006.05.073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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